The Immunohistochemical Expression of the Oestrogen Receptor (ER), HER-2/ne u and Cytokeratin 8/18 and 5/6 in Invasive
Breast Carcinoma
Published: November 1, 2012 | DOI: https://doi.org/10.7860/JCDR/2012/.2542
Bharti Rattan, Mridu Manjari, S.K. Kahlon, Nikita Kalra, Amarpreet Bhalla, Surinder Paul
1. Senior Resident, Government Medical College
Amritsar, Punjab, India.
2. Professor and Head, Government Medical College
Amritsar, Punjab, India.
3. Practitioner, Government Medical College
Amritsar, Punjab, India.
4. Practitioner, Government Medical College
Amritsar, Punjab, India.
5. Senior Resident, Government Medical College
Amritsar, Punjab, India.
6. Associate Professor, Government Medical College
Amritsar, Punjab, India.
Correspondence
Dr. Bharti Rattan
372 Sec 12, Panchkula Haryana-134112 (India).
Phone: 09417039834
E-mail: rattanbharti.rattan@gmail.com
An immunohistochemical study was done on 39 cases of invasive breast carcinoma for further sub-classification, for predicting their prognosis and therapeutic approaches. These cases were evaluated for the expression of cytokeratin Ck 8/18, ER and Her-2/neu and 28 cases were subjected to the evaluation of cytokeratin Ck 5/6, which especially included the cases which were negative for all the three markers. ER was positive in 7 cases, with Her-2/neu being positive in 8 cases and cytokeratin 8/18 being positive in 33 cases. Cytokeratin 5/6 was positive in 7 cases, with 4 cases showing Ck 5/6 and Ck8/18 positivity, 3 cases showing positivity for Ck 5/6 only and 3cases showing negativity for all the 4 markers. Thus they were classified as the luminal A, luminal B, combined, basal and the null types respectively.
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